Select Currency
Translate this page

ANTI-HYPERLIPIDEMIC POTENTIAL OF VITEX DONIANAETHANOLEXTRACTS ON POLOXAMER 407 INDUCED HYPERLIPIDEMIC AND NORMAL RATS

Format: MS WORD  |  Chapter: 1-5  |  Pages: 103  |  2631 Users found this project useful  |  Price NGN5,000

  DOWNLOAD THE FULL PROJECT

ANTI-HYPERLIPIDEMIC POTENTIAL OF VITEX DONIANAETHANOLEXTRACTS ON POLOXAMER 407 INDUCED HYPERLIPIDEMIC AND NORMAL RATS

 

ABSTRACT

Anti-hyperlipidemic potential of extracts (aqueous, 70% methanol, 70% ethanol and 70%, acetone) of Vitexdoniana leaves, stem bark and root bark on poloxamer 407 induced hyperlipidemic and normal rats was investigated. Phytochemical screening of the extracts revealed the presence of flavonoids, saponins, cardiac glycosides, alkaloids and tannins in the leaves, stem bark and root bark. The average total polyphenol contents of the leaves ethanol (36.11±3.13mg/g gallic acid) and methanol (35.75±1.72mg/g gallic acid) extracts were significantly (p<0.05) higher when compared with that of acetone and aqueous extracts. The IC50of the leaves ethanol extract (0.227mg/ml) was lowerthan that ofstem bark ethanol extract (0.236mg/ml) and root ethanol extract (0.561mg/ml). Screening the extracts for the most potent anti-hyperlipidemicactivityreveals that ethanolic extracts of root bark and leaveshas the highest percentage reduction of total cholesterol (51.98%) and triacylglycerol (50.75%) respectively. The most abundant phytochemical in the most potent extract is flavonoid (4.605±0.077%) in the leaves and the least is tanins (0.035±0.008%) in the root bark extract. The LD50 of both leaves and stem bark was greater than 5000mg/kg body weight and that of root bark was 948.68 mg/kg body weight. Hyperlipidemic control rats significantly (p<0.05) increased total Cholesterol (TC), Triacylglycerol (TAG), Low density lipoprotein (LDL-c) andsignificantly (p<0.05) decreased High density lipoprotein (HDL-c) compared to other groups.Atherogenic risk factor of all induced treated rats shows a significant (p<0.05) lower levels of LDL-c/HDL-c, Log (TAG/HDL-c) and significant (p<0.05) higher level of HDL-c /TC ratio. There was no significant (p>0.05) change between normal control rats and normal treated rats in lipid profile parameters and atherogenic indices. The level of liver marker enzymes (ALT, ALP, AST) and liver function parameter (TB, IB) were significantly (p<0.05)higher, and lower (TB, DB) in hyperlipidemic control groups compared to all other groups. The invivo antioxidant activity shows a significantly (p<0.05) higher level of TBARS and a significant (p<0.05) lower level of SOD and CAT in hyperlipidemic groups when compared to all treated groups. In both liver and kidney, the leaves and stem bark extract significantly (p<0.05) lowers levels of TBARS of normal control rats compared to normal treated and all induced treated groups. All the extracts activity in the liver and leaves extract in the kidney of normal rats show a significant higher level of CAT compared with other treated groups. The study shows that vitexdoniana possesses anti-hyperlipidemic potential.

 

INTRODUCTION

Polyphenols arenaturalorganic chemicals characterized by the presence of large number of phenol structural units (Quideauet al., 2011). The most research-informed and chemistry-aware definition of polyphenol is termed the White–Bate-Smith–Swain–Haslam (WBSSH) definition (Haslam and Cai, 1994) which describes the polyphenol as moderately water-soluble compounds, with molecular weight of 500–4000 Dalton,having more than 12 phenolic hydroxyl groups and with 5–7 aromatic rings per 1000 Da.The number and characteristics of the phenol structures underlie the unique physical, chemical, and biological properties of a particular member of the polyphenol class(Quideau et al., 2011).

Over the past 10 years, researchers and food manufacturers have become increasingly interested in polyphenols. The main reason for this interest is the recognition of the antioxidant properties of polyphenols, their great abundance in our diet, and their probable role in the prevention of various diseases associated with oxidative stress, such as cardiovascular, cancer and neurodegenerative diseases. As the major active substance found in many medicinal plants, itmodulates the activity of a wide range of enzymes and cell receptors.Polyphenols as antioxidants, helps in addressing and reversing the problems caused by oxidative stress to the walls of arteries, create a heart-healthy environment by curbing the oxidation of low density lipoprotein cholesterol which stops the potential for atherosclerosis, and they help relieve chronic pain, as seen in conditions like rheumatoid arthritis, due to their anti-inflammatory properties. In addition to having antioxidant properties, polyphenols have several other specific biological actions that are yet to be understood(Quideau et al., 2011).

Plants has been a source of medicinal agents for thousands of years, and an impressive number of modern drugs have been isolated from natural sources, many based on their use in traditional medicine (Hostettmann et al., 2000). These plants continue to play an essential role in health care, with about 90% of the world‟s inhabitants depending mainly on traditional medicines for their primary health care (Hostettmann et al., 2000). Recently, there has been an upsurge of interest in the therapeutic potentials of medicinal plants antioxidants reducing free radical related diseases. It has been mentioned that the antioxidant activity of plants might be due to their phenolic compounds (Cook and Samman, 1996).

  DOWNLOAD THE FULL PROJECT

ANTI-HYPERLIPIDEMIC POTENTIAL OF VITEX DONIANAETHANOLEXTRACTS ON POLOXAMER 407 INDUCED HYPERLIPIDEMIC AND NORMAL RATS

Not The Topic You Are Looking For?



For Quick Help Chat with Us Now!

+234 813 292 6373

+233 55 397 8005


HOW TO GET THE COMPLETE PROJECT ON ANTI-HYPERLIPIDEMIC POTENTIAL OF VITEX DONIANAETHANOLEXTRACTS ON POLOXAMER 407 INDUCED HYPERLIPIDEMIC AND NORMAL RATS INSTANTLY

  • Click on the Download Button above.
  • Select any option to get the complete project immediately.
  • Chat with Our Instant Help Desk on +234 813 292 6373 for further assistance.
  • All projects on our website are well researched by professionals with high level of professionalism.

Here's what our amazing customers are saying

Musa From Ahmadu Bello University
Thank you iprojectmaster for saving my life, please keep it up and may God continue to bless you people.
Excellent
Peace From Unilag
I cried not knowing how to go about my project but the day i searched online and saw iprojectmaster, i called and got my full project in less than 15minutes, i was shocked!
Excellent
Adam Alhassan Yakubu
UDS
Excellent work and delivery , I promise to share my testimonies everyone in need of this kind of work. You're the best
Excellent
Samuel From Ajayi Crowther University
You guys just made life easier for students. Thanks alot iprojectmaster.com
Excellent
Oluchi From Michael Opara University
If you are a student and you have not used iprojectmaster materials, you are missing big time! iprojectmaster is the BEST
Excellent
Abdul Mateen Iddrisu
UDS
At first I taught is a site full of fraudsters until I saw my project in my Gmail after my payment.. THANK YOU IPROJECTMASTER and May God the almighty bless u guys abundantly
Excellent
Azeez Abiodun
Moshood Abiola polytechnic
I actually googled and saw about iproject master, copied the number and contacted them through WhatsApp to ask for the availability of the material and to my luck they have it. So there was a delay with the project due to the covid19 pandemic. I was really scared before making the payment cause I’ve been scammed twice, they attended so well to me and that made me trust the process and made the payment and provided them with proof, I got my material in less than 10minutes
Very Good
Ibrahim Muhammad Muhammad
Usmanu danfodiyo university, sokoto
It's a site that give researcher student's to gain access work,easier,affordable and understandable. I appreciate the iproject master teams for making my project work fast and available .I will surely,recommend this site to my friends.thanks a lot..!
Excellent
Joseph M. Yohanna
Thanks a lot, am really grateful and will surely tell my friends about your website.
Excellent
Merry From BSU
I am now a graduate because of iprojectmaster.com, God Bless you guys for me.
Excellent

FREQUENTLY ASKED QUESTIONS

How do I get this complete project on ANTI-HYPERLIPIDEMIC POTENTIAL OF VITEX DONIANAETHANOLEXTRACTS ON POLOXAMER 407 INDUCED HYPERLIPIDEMIC AND NORMAL RATS?

Simply click on the Download button above and follow the procedure stated.

I have a fresh topic that is not on your website. How do I go about it?

How fast can I get this complete project on ANTI-HYPERLIPIDEMIC POTENTIAL OF VITEX DONIANAETHANOLEXTRACTS ON POLOXAMER 407 INDUCED HYPERLIPIDEMIC AND NORMAL RATS?

Within 15 minutes if you want this exact project topic without adjustment

Is it a complete research project or just materials?

It is a Complete Research Project i.e Chapters 1-5, Abstract, Table of Contents, Full References, Questionnaires / Secondary Data

What if I want to change the case study for ANTI-HYPERLIPIDEMIC POTENTIAL OF VITEX DONIANAETHANOLEXTRACTS ON POLOXAMER 407 INDUCED HYPERLIPIDEMIC AND NORMAL RATS, What do i do?

Chat with Our Instant Help Desk Now: +234 813 292 6373 and you will be responded to immediately

How will I get my complete project?

Your Complete Project Material will be sent to your Email Address in Ms Word document format

Can I get my Complete Project through WhatsApp?

Yes! We can send your Complete Research Project to your WhatsApp Number

What if my Project Supervisor made some changes to a topic i picked from your website?

Call Our Instant Help Desk Now: +234 813 292 6373 and you will be responded to immediately

Do you assist students with Assignment and Project Proposal?

Yes! Call Our Instant Help Desk Now: +234 813 292 6373 and you will be responded to immediately

What if i do not have any project topic idea at all?

Smiles! We've Got You Covered. Chat with us on WhatsApp Now to Get Instant Help: +234 813 292 6373

How can i trust this site?

We are well aware of fraudulent activities that have been happening on the internet. It is regrettable, but hopefully declining. However, we wish to reinstate to our esteemed clients that we are genuine and duly registered with the Corporate Affairs Commission as "PRIMEDGE TECHNOLOGY". This site runs on Secure Sockets Layer (SSL), therefore all transactions on this site are HIGHLY secure and safe!