Select Currency
Translate this page

THE ROLE OF N-BUTANOL LEAF FRACTION OF TELFAIRIA OCCIDENTALIS ON SOME HAEMATOLOGICAL PARAMETERS IN PHENYL-HYDRAZINE INDUCED ANEMIA IN WISTAR RATS

Format: MS WORD  |  Chapter: 1-5  |  Pages: 82  |  1620 Users found this project useful  |  Price NGN3,000

  DOWNLOAD THE FULL PROJECT

ABSTRACT

Anemia is a serious health problem especially in developing countries. In the tropics, rural dwellers had resort to herbal treatment in some cases of anemia. The main aim of this work was to ascertain the role of n-butanol leaf fraction of Telfairia Occidentalis on some haematological parameters in phenyl hydrazine induced anemia in wistar rats. Thirty (30) adult Wistar rats were used for this study. All animals were assayed for haematological parameters 1day before the onset of the experiment. The animals were grouped into five groups of five rats each (n =5). Anemia was induced in the Wistar rats by intraperitoneal injection of Phenyl hydrazine Hydrochloride 50mg/kg w/w in DSMO once daily for 3 days. Group i. serves as the negative control group, received 50mg/kg of Phenylhydrazine Hydrochloride and 1ml/kg normal saline (untreated) group ii. serve as Positive control group received Vitamin B12 0.4ml/kg (standard haematinic) intramuscularly,while group iii, iv. and v. received 100mg/kg, 200mg/kg and 300mg/kg body weight of n-butanol leaf fraction of Telfairia occidentalis for 2 weeks respectively. Asessment of RBC and WBC was carried out using the newly improved Neubauer counting chamber, PCV using the microhaematocrit reader, Hb using the AO-Hb meter and Bilirubin concentration using colorimetric estimation for the serum bilirubin. There was a significant (P<0 .05="" after="" and="" as="" bilirubin="" compared="" concentration="" control="" fraction="" groups="" hb="" in="" increase="" level="" of="" pcv="" rbc="" respectively.="" span="" the="" to="" treatment="" with="" x10="">6/ʯL as compared to 4.78±0.17x106/ʯL), PCV (50.60±0.51% as compared to 37.08±0.37%), HB (16.84±0.18 g/dl as compared to 12.56±0.13 g/dl), WBC (6.10±0.15 x109/L as compared to 6.17±0.88x109/L) and Bilirubin (18.16±0.08a ʯmol/L as compared to 15.54±0.21 ʯmol/L). However, the significant increase obtained from the results of RBC ,PCV and Bilurubin was not dose dependent while that of HB and WBC was dose dependent. In conclusion, Intraperitoneal administration of 50mg/kg Phenylhydrazine hydrochloride for 3days decreases the blood parameters below the pre-anemic level (1day before induction) due to the production of reactive oxygen species. Phytochemical screening of this leaf fraction indicates the presence of flavonoids, saponin secoiridoid glycosides and alkaloids, these natural antioxidants could be responsible for reversing the damaging effect of PHZ and thus playing a modulatory role and also maintaining the integrity of the RBC.

 

CHAPTER ONE

INTRODUCTION

Anemia is a global public health problem affecting both developing and developed countries with major consequences for human health as well as social and economic development (WHO, 2005). Anemia is a reduction from the normal quantity of circulating hemoglobin in the blood less than 13 g/dl for male and less than 12 g/dl for female adults (Okochi et al., 2003). It occurs at all stages of the life cycle, but is more prevalent in pregnant women and young children (Adam et al., 2005). Hemolytic anemia is a form of anemia due to hemolysis, the abnormal breakdown of Red Blood Cells (RBCs), either in the blood vessels (intravascular hemolysis) or elsewhere in the human body (extravascular). It has numerous possible causes, ranging from relatively harmless to life-threatening (Telford et al., 2003). The general classification of hemolytic anemia is either inherited or acquired. Treatment depends on the cause and nature of the breakdown (Yamoto et al., 1998).

Anemia is the result of a wide variety of causes that can be isolated, but more often coexist. Globally, the most significant contributor to the onset of anemia is iron deficiency so that IDA and anemia are often used synonymously, and the prevalence of anemia has often been used as a proxy for IDA (De Maeyer, 1989). It is generally assumed that 50% of the cases of anemia are due to iron deficiency, but the proportion may vary among population groups and in different areas according to the local conditions (De Maeyer, 1989).

  DOWNLOAD THE FULL PROJECT

THE ROLE OF N-BUTANOL LEAF FRACTION OF TELFAIRIA OCCIDENTALIS ON SOME HAEMATOLOGICAL PARAMETERS IN PHENYL-HYDRAZINE INDUCED ANEMIA IN WISTAR RATS

Not The Topic You Are Looking For?



For Quick Help Chat with Us Now!

+234 814 010 7220

+233 55 385 5526


HOW TO GET THE COMPLETE PROJECT ON THE ROLE OF N-BUTANOL LEAF FRACTION OF TELFAIRIA OCCIDENTALIS ON SOME HAEMATOLOGICAL PARAMETERS IN PHENYL-HYDRAZINE INDUCED ANEMIA IN WISTAR RATS INSTANTLY

  • Click on the Download Button above.
  • Select any option to get the complete project immediately.
  • Chat with Our Instant Help Desk on +234 814 010 7220 for further assistance.
  • All projects on our website are well researched by professionals with high level of professionalism.

Here's what our amazing customers are saying

Samuel From Ajayi Crowther University
You guys just made life easier for students. Thanks alot iprojectmaster.com
Excellent
Temitayo Ayodele
Obafemi Awolowo University
My friend told me about iprojectmaster website, I doubted her until I saw her download her full project instantly, I tried mine too and got it instantly, right now, am telling everyone in my school about iprojectmaster.com, no one has to suffer any more writing their project. Thank you for making life easy for me and my fellow students... Keep up the good work
Very Good
Dau Mohammed Kabiru
Kaduna State College of Education Gidan Waya
This is my first time..Your service is superb. But because I was pressed for time, I became jittery when I did not receive feedbackd. I will do more business with you and I will recommend you to my friends. Thank you.
Very Good
Stancy M
Abia State University, Uturu
I did not see my project topic on your website so I decided to call your customer care number, the attention I got was epic! I got help from the beginning to the end of my project in just 3 days, they even taught me how to defend my project and I got a 'B' at the end. Thank you so much iprojectmaster, infact, I owe my graduating well today to you guys...
Excellent
Musa From Ahmadu Bello University
Thank you iprojectmaster for saving my life, please keep it up and may God continue to bless you people.
Excellent
Oluchi From Michael Opara University
If you are a student and you have not used iprojectmaster materials, you are missing big time! iprojectmaster is the BEST
Excellent
Peace From Unilag
I cried not knowing how to go about my project but the day i searched online and saw iprojectmaster, i called and got my full project in less than 15minutes, i was shocked!
Excellent
Emmanuel Essential
Kogi state University
I actually took the risk,you know first time stuff But i was suprised i received as requested. I love you guys 🌟 🌟 🌟 🌟
Very Good
Azeez Abiodun
Moshood Abiola polytechnic
I actually googled and saw about iproject master, copied the number and contacted them through WhatsApp to ask for the availability of the material and to my luck they have it. So there was a delay with the project due to the covid19 pandemic. I was really scared before making the payment cause I’ve been scammed twice, they attended so well to me and that made me trust the process and made the payment and provided them with proof, I got my material in less than 10minutes
Very Good
MATTHEW NGBEDE
Ahmadu Bello University
I wish I knew you guys when I wrote my first degree project, it took so much time and effort then. Now, with just a click of a button, I got my complete project in less than 15 minutes. You guys are too amazing!
Excellent

FREQUENTLY ASKED QUESTIONS

How do I get this complete project on THE ROLE OF N-BUTANOL LEAF FRACTION OF TELFAIRIA OCCIDENTALIS ON SOME HAEMATOLOGICAL PARAMETERS IN PHENYL-HYDRAZINE INDUCED ANEMIA IN WISTAR RATS?

Simply click on the Download button above and follow the procedure stated.

I have a fresh topic that is not on your website. How do I go about it?

How fast can I get this complete project on THE ROLE OF N-BUTANOL LEAF FRACTION OF TELFAIRIA OCCIDENTALIS ON SOME HAEMATOLOGICAL PARAMETERS IN PHENYL-HYDRAZINE INDUCED ANEMIA IN WISTAR RATS?

Within 15 minutes if you want this exact project topic without adjustment

Is it a complete research project or just materials?

It is a Complete Research Project i.e Chapters 1-5, Abstract, Table of Contents, Full References, Questionnaires / Secondary Data

What if I want to change the case study for THE ROLE OF N-BUTANOL LEAF FRACTION OF TELFAIRIA OCCIDENTALIS ON SOME HAEMATOLOGICAL PARAMETERS IN PHENYL-HYDRAZINE INDUCED ANEMIA IN WISTAR RATS, What do i do?

Chat with Our Instant Help Desk Now: +234 814 010 7220 and you will be responded to immediately

How will I get my complete project?

Your Complete Project Material will be sent to your Email Address in Ms Word document format

Can I get my Complete Project through WhatsApp?

Yes! We can send your Complete Research Project to your WhatsApp Number

What if my Project Supervisor made some changes to a topic i picked from your website?

Call Our Instant Help Desk Now: +234 814 010 7220 and you will be responded to immediately

Do you assist students with Assignment and Project Proposal?

Yes! Call Our Instant Help Desk Now: +234 814 010 7220 and you will be responded to immediately

What if i do not have any project topic idea at all?

Smiles! We've Got You Covered. Chat with us on WhatsApp Now to Get Instant Help: +234 814 010 7220

How can i trust this site?

We are well aware of fraudulent activities that have been happening on the internet. It is regrettable, but hopefully declining. However, we wish to reinstate to our esteemed clients that we are genuine and duly registered with the Corporate Affairs Commission as "PRIMEDGE TECHNOLOGY". This site runs on Secure Sockets Layer (SSL), therefore all transactions on this site are HIGHLY secure and safe!