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EVALUATING THE IN-VIVO EFFECTS OF METHANOLIC EXTRACT OF A. BOONEI ON LIVER ENZYME FUNCTION IN ALLOXAN INDUCED DIABETES MELLITUS

CHAPTER ONE

INTRODUCTION

1.1 Background of the Study

Aframomum boonei, commonly known as African nutmeg or Ata-ieye in Yoruba, is a plant widely used in traditional medicine across Africa. It possesses various pharmacological properties, including antioxidant and anti-inflammatory effects. The methanolic extract of A. boonei has shown promising potential in the management of diabetes mellitus, a metabolic disorder characterized by impaired glucose metabolism. Diabetes mellitus often leads to complications affecting various organs, including the liver. Therefore, investigating the effects of A. boonei extract on liver enzyme function in diabetes mellitus is crucial for understanding its therapeutic potential in managing this condition.

The present decade has witnessed a great and intense resurgence in the interest and use of the plant (Briskin., 2000). The healing power of herbs identified and botanical medicine has been one of the oldest practiced professions by humanity (Oduolaet al ., 2007). In fact, the use of synthetic pharmaceutical products and hepatotoxic agent reported not only to connect or some serious adverse effects but these drugs are costly and not within the reach of all. However, traditional use of herbs to promote healing is not an alien in any continent. Diabetes mellitus represents a group of metabolic disorders in which there is an impaired glucose utilization hyperglycaemia which is an increase in the blood glucose level beyond normal values (Hazuda, 1991; Adonu et al., 2013). Diabetes is a chronic disease characterized by elevated blood glucose level and disturbances in carbohydrate, fat and protein metabolism (Sky, 2000; Rother, 2007).

A. boonei De Wild belongs to the family Apocynaceae. It is a large evergreen tree and is one of the most widely used medicinal plants in Africa and beyond. It is distributed throughout the tropics and the rain forest of west and Central Africa (Oliver-Bever, 1986; Olajide, et al., 2000). It is known by different names in different cultures and tribal settings. The plant parts are claimed to have medicinal properties in some cultures and climes. In the local markets in West and Central Africa, Alstoniaboonei is often among the most common sold plant as crude drugs. Parts of the plant are employed for the treatment of a variety of ailments in Africa and the stem bark has been listed in the Africa Pharmacopoeia as an antimalarial drug (Bello et al ., 2009). Various pharmacological studies have been carried out on this plant products which

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